Severe Dry Eye in CD25 Deficiency Syndrome

Bas Z., Bayraktutar B. N., Ucakhan Ö. Ö.

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, vol.44, no.1, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1097/icl.0000000000000346
  • Journal Name: EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: CD25 deficiency, Dry eye, Ocular surface, Topical cyclosporin A, Meibomian gland dysfunction, GLAND DYSFUNCTION, ALPHA-CHAIN, CORNEAL, EXPRESSION, PHENOTYPE, MUTATION, MICE
  • Ankara University Affiliated: Yes

Abstract

CD25 deficiency (Interleukin-2 receptor alpha deficiency) is a rare subtype of combined B- and T-cell immunodeficiency. Recurrent infections and lymphocyte infiltration of multiple tissues are the main clinical presentations. Only four patients have been reported in whom ophthalmological findings were not described. In this article, ocular findings of CD25 deficiency in a 12-year-old child are highlighted.