Trace element levels in Hashimoto thyroiditis patients with subclinical hypothyroidism

Erdal M., ŞAHİN M., Hasimi A., Uckaya G., Kutlu M., Saglam K.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.123, no.1-3, pp.1-7, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 1-3
  • Publication Date: 2008
  • Doi Number: 10.1007/s12011-008-8117-8
  • Journal Name: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-7
  • Keywords: trace elements, subclinical hypothyroidism, TSH, AUTOIMMUNE-THYROIDITIS, RISK-FACTORS, SELENIUM, DISEASE, DYSFUNCTION, CONSENSUS, COPPER, SERUM, ZINC, ASSOCIATION
  • Ankara University Affiliated: No

Abstract

The present study was conducted to evaluate the serum copper, zinc, magnesium, and selenium levels in patients with subclinical hypothyroidism in the iodine-rich region of Ankara, Turkey. The effects of hormone replacement therapy on these elements were also studied in these patients. Basal levels of selenium and iron in patients were significantly lower than control group (67.7 +/- 10.4 vs. 83.7 +/- 17.3 mu g/dl, p=0.02; 55.7 +/- 38 vs 275.7 +/- 24, P=0.03 mu g/dl). Serum magnesium levels were significantly higher in patient group (2.16 +/- 0.31 vs 1.95 +/- 0.13 mg/dl, P < 0.0001). There was a correlation between selenium levels with hsCRP (r=-0.408, p=0.007). HsCRP levels in patients with selenium levels <80 mu g/l (n=31) was significantly higher than hsCRP levels in patients with selenium levels >80 mu g/l (n=12; 1.99 +/- 1.0; 1.02 +/- 0.9, p=0.014). None of these biochemical risk factors and trace elements have changed after euthyroidism in patients with SH when compared to pretreatment levels. Selenium deficiency may contribute to cardiovascular disease risk in these patients.