Studies on the synthesis of some new substituted benzylamino and phenyl-acrylamido-methyl flavone derivatives
MEDICINAL CHEMISTRY RESEARCH, cilt.16, sa.4, ss.170-178, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 4
- Basım Tarihi: 2007
- Doi Numarası: 10.1007/s00044-007-9021-z
- Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.170-178
- Anahtar Kelimeler: flavone derivatives, antimicrobial activity, synthesis
- Ankara Üniversitesi Adresli: Evet
Özet
The synthesis and biological activity of a new series of 2-{3-[substituted benzylamino-methyl)-phenyl]-4H-benzopyrane-4-one (IVa-e) and N-substituted benzyl-N-[3-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamide (Va-e) derivatives are reported. The synthesized compounds were tested in vitro for antifungal and antibacterial activities. Compound IVa showed the best antifungal activity compared with miconazole (CAS 22916-47-8). Compound IVc indicated the best antibacterial activity compared with the control drug ampicillin (CAS 69-53-4).