Studies on the synthesis of some new substituted benzylamino and phenyl-acrylamido-methyl flavone derivatives

Ceylan-Uenluesoy M., Bozdag-Duendar O., ALTANLAR N., Ertan R.

MEDICINAL CHEMISTRY RESEARCH, cilt.16, sa.4, ss.170-178, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00044-007-9021-z
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.170-178
  • Anahtar Kelimeler: flavone derivatives, antimicrobial activity, synthesis
  • Ankara Üniversitesi Adresli: Evet

Özet

The synthesis and biological activity of a new series of 2-{3-[substituted benzylamino-methyl)-phenyl]-4H-benzopyrane-4-one (IVa-e) and N-substituted benzyl-N-[3-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamide (Va-e) derivatives are reported. The synthesized compounds were tested in vitro for antifungal and antibacterial activities. Compound IVa showed the best antifungal activity compared with miconazole (CAS 22916-47-8). Compound IVc indicated the best antibacterial activity compared with the control drug ampicillin (CAS 69-53-4).