Role of Tacrolimus in Preventing Intra-Abdominal Adhesions

Cukurova Anestezi ve Cerrahi Bilimler Dergisi, cilt.9, sa.2, ss.462-468, 2026 (Hakemli Dergi)

Aim: The study aimed to identify whether tacrolimus has preventive effects on intraperi-

toneal adhesions. Methods: Thirty-four 8–10-week-old male Wistar Albino rats were

used. They were randomized into 3 groups; control group, abdominal lavage group, and

systemic administration group. The features of abdominal adhesions were evaluated mac-

roscopically, and the degree of adhesion within rats was graded by using Nair and

Knightly adhesion grading scales. Results: Adhesion grades were significantly lower in

tacrolimus administered groups. However, route of tacrolimus administration did not af-

fect the reduction of adhesion formation. Conclusion: Tacrolimus has been observed to

potentially mitigate the incidence of intraperitone