Facile Synthesis of Novel Pyrimido[1,2-a]pyrimidin-4-ones from Highly Reactive Malonates
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, cilt.2010, sa.11, ss.2113-2120, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2010 Sayı: 11
- Basım Tarihi: 2010
- Doi Numarası: 10.1002/ejoc.200901419
- Dergi Adı: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2113-2120
- Anahtar Kelimeler: Nitrogen heterocycles, Fused-ring systems, Cyclization, Condensation, Malonates, REGIOSELECTIVE SYNTHESIS, HETEROCYCLES, DERIVATIVES, PYRIMIDINE, INHIBITORS, GUANIDINE, ACRYLONITRILE, HYDROXY, ANALOGS
- Ankara Üniversitesi Adresli: Evet
Özet
A very simple and efficient procedure for the synthesis of novel 2-hydroxy-4H-pyrimido[1,2-a]pyrimidin-4-ones is described. Title compounds were obtained from the room temperature reaction of 2-aminopyrimidine and its substituted derivatives with bis(2,4,6-trichlorophenyl) malonates. High product yields were observed under optimized conditions. Applicability and reactivity of a range of substituted and unsubstituted phenyl malonates were also investigated. Structural identification of all new compounds was accomplished by spectroscopic methods and elemental analysis.