Facile Synthesis of Novel Pyrimido[1,2-a]pyrimidin-4-ones from Highly Reactive Malonates

GÜLLÜ M., Dincsonmez A., Ozyavas O.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, cilt.2010, sa.11, ss.2113-2120, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2010 Sayı: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/ejoc.200901419
  • Dergi Adı: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2113-2120
  • Anahtar Kelimeler: Nitrogen heterocycles, Fused-ring systems, Cyclization, Condensation, Malonates, REGIOSELECTIVE SYNTHESIS, HETEROCYCLES, DERIVATIVES, PYRIMIDINE, INHIBITORS, GUANIDINE, ACRYLONITRILE, HYDROXY, ANALOGS
  • Ankara Üniversitesi Adresli: Evet

Özet

A very simple and efficient procedure for the synthesis of novel 2-hydroxy-4H-pyrimido[1,2-a]pyrimidin-4-ones is described. Title compounds were obtained from the room temperature reaction of 2-aminopyrimidine and its substituted derivatives with bis(2,4,6-trichlorophenyl) malonates. High product yields were observed under optimized conditions. Applicability and reactivity of a range of substituted and unsubstituted phenyl malonates were also investigated. Structural identification of all new compounds was accomplished by spectroscopic methods and elemental analysis.