Soluble P-selectin, interleukin 6, and thrombopoietin levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy: A pilot study

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Olcay L., Yenicesu I., Yetgin S.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.24, no.9, pp.742-745, 2002 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 24 Issue: 9
• Publication Date: 2002
• Doi Number: 10.1097/00043426-200212000-00012
• Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.742-745
• Keywords: acute, chronic, idiopathic thrombocytopenic purpura, soluble P-selectin, thrombopoietin, interleukin 6, methylprednisolone, SERUM LEVELS, AUTOIMMUNE, PLATELETS, MICROPARTICLES, ACTIVATION, DISORDERS, PROTEIN, IL-6
• Ankara University Affiliated: No

Abstract

We observed less severe symptoms in patients with chronic idiopathic thrombocytopenic purpura. (ITP) than in patients with acute ITP with similar platelet counts. Thrombopoietin (TPO), soluble P-selectin, soluble P-selectin per platelet, and interleukin 6 (IL-6) were evaluated in children with ITP before treatment in 16 acute and 22 chronic cases and after treatment in 10 acute and chronic cases who received mega-dose methylprednisolone. The levels of IL-6, soluble P-selectin, soluble P-selectin per platelet, and platelet count were similar in acute and chronic ITP (P > 0.05) but TPO in acute ITP was higher than that of the patients with chronic ITP (P < 0.05). The posttreatment IL-6 and TPO declined (P < 0.05), but soluble P-selectin and platelet count increased (P < 0.05). Posttreatment soluble P-selectin per platelet levels were higher than the normal values (P < 0.05). These results suggest that IL-6, soluble P-selectin, and soluble P-selectin per platelet are not responsible for the milder symptoms in chronic than in acute ITP. Mega-dose methylprednisolone seems to keep the soluble P-selectin levels elevated.