RELATIONSHIP BETWEEN ALDOSE REDUCTASE AND SUPEROXIDE DISMUTASE INHIBITION CAPACITIES OF INDOLE-BASED ANALOGS OF MELATONIN DERIVATIVES

Das-Evcimen N., Yildirim Ö., Suzen S.

ARCHIVES OF BIOLOGICAL SCIENCES, cilt.61, sa.4, ss.675-681, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.2298/abs0904675d
  • Dergi Adı: ARCHIVES OF BIOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.675-681
  • Anahtar Kelimeler: Aldose reductase, antioxidant, diabetes mellitus, indole, melatonin, OXIDATIVE STRESS, 2-PHENYLINDOLE DERIVATIVES, ANTIOXIDANT BEHAVIOR, RAT, COMPLICATIONS, ENZYME
  • Ankara Üniversitesi Adresli: Evet

Özet

Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes associated with secondary diabetic complications such as cataract, neuropathy, and nephropathy. Oxidative stress, antioxidants, and the polyol pathway have recently been found to be linked in pathological states. A large number of structurally different compounds have been studied as potent in vitro AR inhibitors (ARIs). However, with few exceptions, these compounds did not show clinical benefit, and some even produced serious side effects. In view of the ARI activity of certain indole derivative compounds and antioxidant properties of melatonin, we investigated some indole-based analogs of melatonin derivatives. Antioxidant and ARI activity tests were applied to nine indole derivatives that are substituted at the third and fifth positions. Also, the relationship between ARI and antioxidant enzyme activity is discussed.