Role of protein kinase C in diabetic complications

King G. L., Das-Evcimen N.

Expert Review of Endocrinology and Metabolism, cilt.5, sa.1, ss.77-88, 2010 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1586/eem.09.74
  • Dergi Adı: Expert Review of Endocrinology and Metabolism
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.77-88
  • Anahtar Kelimeler: Diabetes mellitus, Diabetic complications, LY333531, PKC isoforms, Protein kinase C, Ruboxistaurin
  • Ankara Üniversitesi Adresli: Evet

Özet

Hyperglycemia is an important factor in the development of macrovascular and microvascular complications in all diabetic patients. Several hypotheses have been postulated to explain the adverse effect of hyperglycemia on the vasculature; and one of these hypotheses is the activation of specific isoforms of protein kinase C (PKC) by diabetes. In this review, we summarize the molecular mechanisms of PKC activation and its relationship to diabetic complications. PKC activity regulates vascular permeability, contractility, extracellular matrix synthesis, hormone receptor turnover and proliferation, cell growth, angiogenesis, cytokine activation and leukocyte adhesion. All of these properties are abnormal in diabetes and are correlated with increased diacylglycerol-PKC pathway and PKCα, 1/2 and isoforms activation in the retina, aorta, heart and renal glomeruli. © 2010 Expert Reviews Ltd.