Increased effective immunogenicity to high-dose and short-interval hepatitis B virus vaccination in individuals with chronic hepatitis without cirrhosis

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De Maria N., Idilman R., Colantoni A., Van Thiel D.

JOURNAL OF VIRAL HEPATITIS, vol.8, no.5, pp.372-376, 2001 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 8 Issue: 5
• Publication Date: 2001
• Doi Number: 10.1046/j.1365-2893.2001.00301.x
• Journal Name: JOURNAL OF VIRAL HEPATITIS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.372-376
• Keywords: alcoholic liver disease, chronic liver disease, hepatitis B virus, hepatitis C virus, immunization, vaccine, CHRONIC LIVER-DISEASE, ACTIVATION PATHWAYS, ANTIBODY-RESPONSE, SURFACE-ANTIGEN, INFECTION
• Ankara University Affiliated: Yes

Abstract

Hepatitis B virus (HBV) vaccination is recommended for individuals with chronic liver disease. However, the response to standard doses of hepatitis B vaccines in such individuals has been poor. The aim of the present study was to assess the response to high-dose short-interval HBV vaccination in individuals with chronic liver disease of different aetiologies. A total two hundred and 24 subjects with chronic liver disease (138 chronic active hepatitis and 86 cirrhosis) and 26 healthy controls were vaccinated using a high-dose (40 mug) short-interval (monthly for 3 consecutive months) HBV vaccination schedule.