JOURNAL OF VIRAL HEPATITIS, cilt.8, sa.5, ss.372-376, 2001 (SCI-Expanded)
Hepatitis B virus (HBV) vaccination is recommended for individuals with chronic liver disease. However, the response to standard doses of hepatitis B vaccines in such individuals has been poor. The aim of the present study was to assess the response to high-dose short-interval HBV vaccination in individuals with chronic liver disease of different aetiologies. A total two hundred and 24 subjects with chronic liver disease (138 chronic active hepatitis and 86 cirrhosis) and 26 healthy controls were vaccinated using a high-dose (40 mug) short-interval (monthly for 3 consecutive months) HBV vaccination schedule.