EPCR gene A3 haplotype and elevated soluble endothelial protein C receptor (sEPCR) levels in Turkish pediatric stroke patients

Ulu A., Gunal D., Tiras S., Egin Y., Deda G., Akar N.

THROMBOSIS RESEARCH, cilt.120, sa.1, ss.47-52, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.thromres.2006.08.004
  • Dergi Adı: THROMBOSIS RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.47-52
  • Anahtar Kelimeler: EPCR gene, A3 haplotype, sEPCR levels, pediatric stroke, 23BP INSERTION, PLASMA-LEVELS, RISK, PREVALENCE, MUTATION
  • Ankara Üniversitesi Adresli: Hayır

Özet

Introduction: High plasma levels of sEPCR lead to dysfunction of the EPCR-mediated coagulation. We have evaluated the role of EPCR A3 haplotype with its representative promoter variant 1651 C-G in a total of twenty-seven pediatric stroke patients and fifty-nine healthy subjects.