EPCR gene A3 haplotype and elevated soluble endothelial protein C receptor (sEPCR) levels in Turkish pediatric stroke patients

Ulu, Arzu; Gunal, Denizay; Tiras, SERAP; Egin, Yonca; Deda, Gulhis; Akar, Nejat

doi:10.1016/j.thromres.2006.08.004

EPCR gene A3 haplotype and elevated soluble endothelial protein C receptor (sEPCR) levels in Turkish pediatric stroke patients

Ulu A., Gunal D., Tiras S., Egin Y., Deda G., Akar N.

THROMBOSIS RESEARCH, cilt.120, sa.1, ss.47-52, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 120 Sayı: 1
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.thromres.2006.08.004
Dergi Adı: THROMBOSIS RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.47-52
Anahtar Kelimeler: EPCR gene, A3 haplotype, sEPCR levels, pediatric stroke, 23BP INSERTION, PLASMA-LEVELS, RISK, PREVALENCE, MUTATION
Ankara Üniversitesi Adresli: Hayır

Özet

Introduction: High plasma levels of sEPCR lead to dysfunction of the EPCR-mediated coagulation. We have evaluated the role of EPCR A3 haplotype with its representative promoter variant 1651 C-G in a total of twenty-seven pediatric stroke patients and fifty-nine healthy subjects.