Antioxidant properties of novel benzimidazole retinoids
Archiv der Pharmazie, vol.337, no.4, pp.188-192, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 337 Issue: 4
- Publication Date: 2004
- Doi Number: 10.1002/ardp.200300834
- Journal Name: Archiv der Pharmazie
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.188-192
- Keywords: retinoids, benzimidazoles, lipid peroxidation, LIPID-PEROXIDATION, RETINOBENZOIC ACIDS, DIFFERENTIATION, DERIVATIVES, LIVER
- Ankara University Affiliated: Yes
Abstract
Our approach was to examine the antioxidant activity of novel retinoid derivatives containing the benzimidazole moiety. Their in vitro effects on rat liver microsomal, NADPH-dependent lipid peroxidation levels and superoxide anion formation were determined. Lipid peroxidation in rat liver microsomes was reduced by some of the compounds in a dose-dependent manner.