Antioxidant properties of novel benzimidazole retinoids

ALAGÖZ Z., Can-Eke B., Coban T., Iscan M., Buyukbingol E.

Archiv der Pharmazie, cilt.337, sa.4, ss.188-192, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 337 Sayı: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/ardp.200300834
  • Dergi Adı: Archiv der Pharmazie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.188-192
  • Anahtar Kelimeler: retinoids, benzimidazoles, lipid peroxidation, LIPID-PEROXIDATION, RETINOBENZOIC ACIDS, DIFFERENTIATION, DERIVATIVES, LIVER
  • Ankara Üniversitesi Adresli: Evet

Özet

Our approach was to examine the antioxidant activity of novel retinoid derivatives containing the benzimidazole moiety. Their in vitro effects on rat liver microsomal, NADPH-dependent lipid peroxidation levels and superoxide anion formation were determined. Lipid peroxidation in rat liver microsomes was reduced by some of the compounds in a dose-dependent manner.