Crystal structure of 3,3-dichloro-N-p-methoxyphenyl-4-(2-phenyistryl)-2-azetidinone

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KABAK M., Guner V., Elerman Y., Durlu T.

ANALYTICAL SCIENCES, vol.19, no.6, pp.969-970, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.2116/analsci.19.969
  • Journal Name: ANALYTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.969-970
  • Ankara University Affiliated: Yes

Abstract

3.3-Dichloro-N-p-methoxyphenyl-4-(2-phenylstryl)-2-azetidinone (C22H15Cl2NO2) was studied by X-Ray analysis, which indicated a monoclinic space group, P2(1)/c, with a = 9.619(5), b = 13.879(4), c = 14.161(5)Angstrom, beta = 100. 16(3)degrees, V = 1860.8(13)Angstrom(3), Z = 4, D-c = 1.414 g cm(-3), mu(Mo K-a) = 0.366 mm(-1) and F-000 = 816. The structure was solved by direct methods and refined to R = 0.041 for 4026 reflections [I > 2sigma(I). The beta-lactam ring (2-azetidinone) has antimicrobial affects. The substituents of the methoxyphenyl and phenyl substituents do not change the activity property of the betalactam ring, and the activity properties depend on the planarity of the beta-lactam ring.