Akademik Veri Yönetim Sistemi
International Symposium on Pharmaceutical Sciences, Ankara, Türkiye, 25 - 28 Haziran 2024, ss.297, (Özet Bildiri)
Vitamin C (ascorbic acid-AA) is one of the essential vitamins responsible for various chemical reactions in the human body. It is an antioxidant substance that reduces free radicals, which can pose a risk of various diseases. It acts as a cofactor in biochemical activities. Humans cannot synthesize Vitamin C endogenously; thus, they need to obtain it from foods or dietary supplements (1). The pharmacokinetics data of AA points to a variable bioavailability profile. Thus, there is a need to develop stable drug delivery systems that enhance its bioavailability and pharmacokinetics while prioritizing degradation. Niosomes, which are vesicles with a bilayer structure prepared with non-ionic surfactants similar to liposomes, are considered a better option due to their better chemical stability profile and the ability to modify their surface properties. This study aims to prepare niosomes containing the derivatives of C vitamin and characterize them in vitro (2).