Synthesis and Pharmacologic Evaluation of Some Benzimidazole Acetohydrazide Derivatives as EGFR Inhibitors

Demirel, Serkan; KILCIGİL, GÜLGÜN; Kara, Zumra; GÜVEN, BERNA; BEŞİKCİ, ARZU

doi:10.4274/tjps.24008

Synthesis and Pharmacologic Evaluation of Some Benzimidazole Acetohydrazide Derivatives as EGFR Inhibitors

Demirel S., KILCIGİL G., Kara Z., GÜVEN B., BEŞİKCİ A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.3, ss.285-289, 2017 (ESCI, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 3
Basım Tarihi: 2017
Doi Numarası: 10.4274/tjps.24008
Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.285-289
Anahtar Kelimeler: Benzimidazole, acetohydrazide, epidermal growth factor receptor kinase, inhibitory, TYROSINE KINASE, DISCOVERY, VEGFR-2, ANALOGS, CANCER
Ankara Üniversitesi Adresli: Evet

Özet

Objectives: In this study, some novel 2-(2-phenyl)-1H-benzo[d] imidazol-1-yl)-N'-(arylmethylene) acetohydrazide derivatives (1-12) were designed and synthesized.