Synthesis and Pharmacologic Evaluation of Some Benzimidazole Acetohydrazide Derivatives as EGFR Inhibitors

Demirel S., KILCIGİL G., Kara Z., GÜVEN B., BEŞİKCİ A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.3, ss.285-289, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.24008
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.285-289
  • Anahtar Kelimeler: Benzimidazole, acetohydrazide, epidermal growth factor receptor kinase, inhibitory, TYROSINE KINASE, DISCOVERY, VEGFR-2, ANALOGS, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: In this study, some novel 2-(2-phenyl)-1H-benzo[d] imidazol-1-yl)-N'-(arylmethylene) acetohydrazide derivatives (1-12) were designed and synthesized.