Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D-2

Akarsu E. S., Mamuk S., CÖMERT A.

EPILEPSY RESEARCH, cilt.30, sa.1, ss.63-68, 1998 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 1998
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.63-68
  • Anahtar Kelimeler: PGD(2), PTZ seizure, ZK 118.182, AH 6809, sodium selenite, rat, REGIONAL DISTRIBUTION, D SYNTHASE, BRAIN, NEUTROPHILS, CONVULSIONS, PLATELETS, GERBILS, ANALOG, SLEEP, ACIDS
  • Ankara Üniversitesi Adresli: Evet

Özet

This study was undertaken to evaluate the role of brain PGD(2) activity during PTZ induced seizures in rats. Potentiation of endogenous PGD(2) activity caused an anti-convulsant effect. Thus, after PGD(2) injection (5 mu g/icv) the latency of generalized tonic clonic convulsions was prolonged. ZK 118.182, a stable analogue of PGD(2), dose-dependently inhibited the incidence and the intensity of seizures when injected at doses of 1-100 ng/icv. But on the other hand, inhibition of PGD(2) activity either by a D-type PG receptor antagonist (AH 6809; 50 ng/icv) or by a PGD synthase inhibitor (sodium selenite; 0.2 mu g/icv) produced a proconvulsant effect by increasing the incidence and the intensity of the seizures. These findings indicate that endogenous PGD, activity in the brain may have a specific inhibitory role for the initiation and propagation of PTZ induced seizures in rats. (C) 1998 Elsevier Science B.V. All rights reserved.