Comparison of clopidogrel versus ticlopidine for prevention of minor myocardial injury after elective coronary stenting

Atmaca Y., Dandachi R., GÜLEÇ H. S., DİNÇER İ., Oral D.

INTERNATIONAL JOURNAL OF CARDIOLOGY, sa.2-3, ss.143-149, 2003 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0167-5273(02)00316-9
  • Dergi Adı: INTERNATIONAL JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.143-149
  • Anahtar Kelimeler: minor myocardial injury, clopidogrel, ticlopidine, elective stenting, CARDIAC TROPONIN-T, ASPIRIN PLUS TICLOPIDINE, REVASCULARIZATION PROCEDURES, ANTIPLATELET THERAPY, COMBINATION THERAPY, PLATELET ACTIVATION, UNSTABLE ANGINA, MB MASS, ANGIOPLASTY, IMPLANTATION
  • Ankara Üniversitesi Adresli: Evet

Özet

We searched a randomized, double-blinded, prospective study that compared the effectiveness of clopidogrel versus ticlopidine for prevention of minor myocardial injury (MMI) and major clinical events (MCEs) after elective coronary stenting. A total of 158 consecutive patients (98 male, 60 female patients with a mean age of 59.3+/-5.4 years) were divided into two arms based on treatment with thienopyridines: group I, clopidogrel 1X300 mg as a loading dose, and 1X75 mg per day thereafter, group II, ticlopidine 2X250 mg daily. Both thienopyridines were started on the same day as stent placement. Cardiac troponin T (cTnT) was measured immediately before and 12 h after the procedures. All patients were followed-up during the hospital stay (6+/-2 days) with respect to MMI and MCEs. The increase frequency and the amount of cTnT level in group I was found significantly lower compared with group II (5 vs.15; P<0.01; 0.38+/-0.11 vs. 0.44+/-0.12 ng/ml; P<0.001, respectively). Patients with elevated cTnT levels more likely to have C type lesion (P<0.004). Though there was a trend toward increased major clinical events rate in group II than those of group I, the statistical difference was not different (4 vs. 1.3%; P>0.05). The present study showed that the combination of clopidogrel and aspirin was more effective than the combination of ticlopidine and aspirin in decreasing the rate of MMI. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.