Akademik Veri Yönetim Sistemi
Ankara Üniversitesi Tıp Fakültesi Mecmuası, cilt.75, sa.1, ss.103-106, 2022 (Hakemli Dergi)
Objectives: Sorafenib is one of the standard anti-cancer drugs in the treatment of radioactive iodine refractory (RR) metastatic differentiated thyroid cancer (DTC). In this study, we aimed to present a long-term real-life experience of sorafenib in the treatment of (RR) metastatic (DTC). Materials and Methods: We retrospectively searched the patients’ records for RR metastatic DTC patients treated with sorafenib in a tertiary cancer center between 01.01.2014 and 31.12.2019. Progression-free survival (PFS), overall survival (OS), response rates, and safety profile of sorafenib were assessed. Results: A total of 19 patients were included in this study. The majority of patients had papillary thyroid cancer (80%). With a median follow-up of 18 months, the median PFS and OS were 10.9 and 41 months, respectively. The objective response rate and disease control rate were 36% and 68%, respectively. Nine patients (45%) reported any adverse events (AEs) with sorafenib. Conclusion: This long-term real-life experience study showed that the median OS was longer than 3 years in RR metastatic DTC patients treated with sorafenib. On the other hand, AEs rates were lower in our study than in the pivotal phase III trial of sorafenib in RR DTC patients