Non-Infectious Early Complications of Allogeneic Stem Cell Transplantations

Atilla P. A., Atilla E., TOPRAK S. K., DEMİRER T.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.26, sa.4, ss.239-250, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4999/uhod.161302
  • Dergi Adı: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.239-250
  • Anahtar Kelimeler: Early Complication, Non-Infectious, Allogeneic stem cell transplantation, HEPATIC VENOOCCLUSIVE DISEASE, HIGH-DOSE CHEMOTHERAPY, BONE-MARROW-TRANSPLANTATION, TOTAL-BODY IRRADIATION, SINUSOIDAL OBSTRUCTION SYNDROME, CHRONIC MYELOGENOUS LEUKEMIA, COLONY-STIMULATING FACTOR, POOR GRAFT FUNCTION, THROMBOTIC MICROANGIOPATHY, BREAST-CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative option in many benign and malign hematological disorders. Recent developments in posttransplant supportive care, graft versus host disease (GVHD) prophylaxis and treatment as well as reduced intensity conditioning regimens (RIC) have improved posttransplant survival. However, infections, GVHD related organ injury, increased incidence of human leukocyte antigen (HLA) mismatched unrelated or haploidentical transplantations effect post transplant mortality in a negative manner. Allo-HSCT related complications can be classified into early (within 3 months of transplantation) and long term complications (after 3 months of transplantation). Some early complications which will be briefly discussed in this review are graft failure, sinusoidal obstruction syndrome, capillary leak syndrome, engraftment syndrome, diffuse alveolar hemorrhage and thrombotic microangiopathy.