Comparison of OCT findings of schizophrenia patients using FGA, Clozapine, and SGA other than Clozapine


Orum M. H., Bulut M., Karadag A. S., Dumlupinar E., Kalenderoglu A.

ARCHIVES OF CLINICAL PSYCHIATRY, cilt.47, sa.6, ss.165-175, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.15761/0101-60830000000257
  • Dergi Adı: ARCHIVES OF CLINICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.165-175
  • Anahtar Kelimeler: Antipsychotics, Retinal Ganglion Cell, Choroid, Optical Coherence Tomography, Schizophrenia, GANGLION-CELL LAYER, ANTIPSYCHOTIC-DRUGS, STRUCTURAL-CHANGES, INHIBITION, EXPRESSION, APOPTOSIS, DISORDER, VOLUMES, RAT
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: The effect of antipsychotic (AP) drugs on optical coherence tomography (OCT) findings in schizophrenia has not yet been fully elucidated. In this study, we aimed to investigate the effects of APs (the first generation antipsychotic group [FGAG], the second generation antipsychotic group [SGAG], the clozapine group [CG]) on OCT findings in schizophrenia. Methods: The thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroidal thickness were measured using a spectral OCT device. Results: No significant difference was found between FGAG, SGAG, CG (p > 0.05) while there was a significant difference between the control group and the patients group in terms of RNFL, GCL, and IPL (p < 0.05). A significant difference between SGAG and CG, FGAG (p < 0.05); between control group and FGAG (p < 0.05) were found in terms of choroidal thickness. Conclusion: These findings suggested the deterioration of the metabolic parameters due to the SGA use. Thinner choroidal layer thickness in the CG compared to the SGAG and control group was thought to be related to the patients using clozapine had a resistance to the treatment.