May zoledronic acid have negative effects on cognition and muscle performance?

Bahsi R., ATMIŞ V., Turgut T., Surmeli D. M., COŞARDERELİOĞLU SEÇER Ç., Oztorun H. S., ...Daha Fazla

IRISH JOURNAL OF MEDICAL SCIENCE, cilt.189, sa.1, ss.191-196, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 189 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s11845-019-02086-5
  • Dergi Adı: IRISH JOURNAL OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.191-196
  • Anahtar Kelimeler: Cognitive function, Gait speed, Zoledronic acid, SHORT-FORM, BISPHOSPHONATES, MEN, OSTEOPOROSIS, EFFICACY, INFUSION, SAFETY, DELIRIUM, THERAPY, WOMEN
  • Ankara Üniversitesi Adresli: Evet

Özet

BackgroundWe aimed to investigate the effects of zoledronic acid treatment on daily living activities, cognitive functions, depression, muscle strength, and performance.MethodsThe study was conducted retrospectively. Bone mineral densitometry (BMD) values, Katz activities of daily living (ADL), Lawton-Brody instrumental activities of daily living (IADL), mini mental state examination (MMSE), geriatric depression scale (GDS), mini nutritional assessment (MNA), grip strength, and gait speed scores before and 6 months after zoledronic acid administration were compared.ResultsA total of 115 patients were included in the study. There was a significant increase in lumbar total (p<.001), femoral neck (p=.002), and femur total (p=.001) BMD values after zoledronic acid treatment. Significant decrease was found in MMSE (p=.016) and gait speed scores (p=.008) after zoledronic acid treatment, but no significant difference was found in terms of Katz ADL, Lawton-Brody IADL, MNA, GDS, and grip strength (p>.05).ConclusionOur study indicated that zoledronic acid did not affect daily living activities, depression, and muscle strength. Although we have concluded that cognitive and muscle performance may be adversely affected by zoledronic acid treatment.