Akademik Veri Yönetim Sistemi
Acta Pharmaceutica Turcica, cilt.39, sa.2, ss.77-80, 1997 (Scopus)
The sensitivity and responsiveness of direct and indirect (antiadrenergic) effects of adenosine in the isolated left atrial preparations of streptozotocin-induced diabetic rats were examined Diabetes was induced with streptozotocin (45 mg/kg). After 12 weeks atrial responses to direct and indirect effects of adenosine were assessed using an isolated left atrial preparations. Diabetic rats at 12 weeks after the induction of diabetes showed a significant increase to direct and indirect inotropic effect of adenosine. APT-sensitive K+channel blocker glibenclamide prevented only enhanced responses to adenosine induced direct inotropic effect but not indirect inotropic effect.