Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Fusco, Laura; Orecchioni, Marco; Reina, Giacomo; Bordoni, Valentina; Fuoco, Claudia; Gurcan, Cansu; Guo, Shi; Zoccheddu, Martina; Collino, Federica; Zavan, Barbara; Treossi, Emanuele; YILMAZER AKTUNA, AÇELYA; Palermo, Vincenzo; Bianco, Alberto; Delogu, Lucia

doi:10.1016/j.impact.2021.100330

Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Atıf İçin Kopyala

Fusco L., Orecchioni M., Reina G., Bordoni V., Fuoco C., Gurcan C., ...Daha Fazla

NANOIMPACT, cilt.23, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.impact.2021.100330
Dergi Adı: NANOIMPACT
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Carbon materials, 2D materials, Single-cell, Biocompatibility, Cytotoxicity, Safety, MASS CYTOMETRY, OXIDE, NANOCOMPOSITES, VISUALIZATION, HETEROGENEITY, REDUCTION, RESPONSES, IMPACT, SHAPE
Ankara Üniversitesi Adresli: Evet

Özet

Given the wide variety of potential applications of graphene oxide (GO), its consequent release into the environment poses serious concerns on its safety. The future production and exploitation of graphene in the years to come should be guided by its specific chemical-physical characteristics. The unparalleled potential of single-cell mass cytometry (CyTOF) to dissect by high-dimensionality the specific immunological effects of nanomaterials, represents a turning point in nanotoxicology. It helps us to identify the safe graphene in terms of physical chemical properties and therefore to direct its future safe production.