Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Fusco, Laura; Orecchioni, Marco; Reina, Giacomo; Bordoni, Valentina; Fuoco, Claudia; Gurcan, Cansu; Guo, Shi; Zoccheddu, Martina; Collino, Federica; Zavan, Barbara; Treossi, Emanuele; YILMAZER AKTUNA, AÇELYA; Palermo, Vincenzo; Bianco, Alberto; Delogu, Lucia

doi:10.1016/j.impact.2021.100330

Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Fusco L., Orecchioni M., Reina G., Bordoni V., Fuoco C., Gurcan C., ...More

NANOIMPACT, vol.23, 2021 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 23
Publication Date: 2021
Doi Number: 10.1016/j.impact.2021.100330
Journal Name: NANOIMPACT
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Carbon materials, 2D materials, Single-cell, Biocompatibility, Cytotoxicity, Safety, MASS CYTOMETRY, OXIDE, NANOCOMPOSITES, VISUALIZATION, HETEROGENEITY, REDUCTION, RESPONSES, IMPACT, SHAPE
Open Archive Collection: AVESIS Open Access Collection
Ankara University Affiliated: Yes

Abstract

Given the wide variety of potential applications of graphene oxide (GO), its consequent release into the environment poses serious concerns on its safety. The future production and exploitation of graphene in the years to come should be guided by its specific chemical-physical characteristics. The unparalleled potential of single-cell mass cytometry (CyTOF) to dissect by high-dimensionality the specific immunological effects of nanomaterials, represents a turning point in nanotoxicology. It helps us to identify the safe graphene in terms of physical chemical properties and therefore to direct its future safe production.