CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population

SÜZEN H. S., Gucyener E., Sakalli O., Uckun Z., Kose G., Ustel D., ...Daha Fazla

MOLECULAR BIOLOGY REPORTS, cilt.37, sa.1, ss.87-92, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s11033-009-9540-4
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.87-92
  • Anahtar Kelimeler: CAT, GPX1, Polymorphism, Turkish, OXIDATIVE STRESS, SUPEROXIDE-DISMUTASE, ANTIOXIDANT ENZYMES, BREAST-CANCER, CATALASE GENE, RISK, GLUTATHIONE-PEROXIDASE-1, PHENOTYPE, VARIANTS
  • Ankara Üniversitesi Adresli: Evet

Özet

Oxidative stress is believed to play an important role in the pathogenesis of considerable number of complex diseases. The antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) are important components of cell defense against oxidative stress, and polymorphisms in the genes which regulate their expression may contribute to differences in susceptibility of individuals to oxidative damage caused by reactive oxygen species. The aim of this study was to assess the distribution of CAT C-262T and GPX1 Pro198Leu genotypic variants in a Turkish population. Genotyping analyses of CAT and GPX1 were conducted in 250 unrelated, healthy volunteers by the PCR-RFLP assay. The allele frequencies were 0.784 (C) and 0.216 (T) for CAT and 0.636 (C) and 0.364 (T) for GPX1 Pro198Leu. The genotype frequencies were 0.632 (CC), 0.304 (CT), and 0.064 (TT) for CAT and 0.416 (CC), 0.44 (CT), and 0.144 (TT) for GPX1 Pro198Leu. The genotype frequencies did not deviate from Hardy-Weinberg equilibrium. The results are compared with those of other reported populations. They showed marked ethnic group differences.