Electrochemical reduction and oxidation of the antibiotic cefepime at a carbon electrode

Ozkan S. A., Uslu B., Zuman P.

Analytica Chimica Acta, cilt.457, sa.2, ss.265-274, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 457 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0003-2670(02)00022-3
  • Dergi Adı: Analytica Chimica Acta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.265-274
  • Anahtar Kelimeler: cefepime, voltammetry, carbon electrode, CEPHALOSPORIN ANTIBIOTICS, VOLTAMMETRY
  • Ankara Üniversitesi Adresli: Evet

Özet

The O-methyl oxime grouping in the antibiotic cefepime is reduced in aqueous buffer solution at pH<8 at a carbon electrode. The reduction of the protonated form of the oxime occurs in a single two-electron step. By comparison with anodic wave of 2-aminothiazole it was furthermore shown that the oxidation of cefepime involves the 2-amino group located on the thiazole ring in the side chain on C-7. Both reduction and oxidation peaks can be used for analytical purposes. © 2002 Elsevier Science B.V. All rights reserved.