Optimizing nitric oxide production by time dependent L-arginine administration in isolated human corpus cavernosum

GÜR S., Kadowitz P. J., Trost L., Hellstrom W. J. G.

JOURNAL OF UROLOGY, vol.178, no.4, pp.1543-1548, 2007 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 178 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1016/j.juro.2007.05.121
  • Journal Name: JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1543-1548
  • Keywords: penis, impotence, sildenafil, arginine, muscle relaxation, SMOOTH-MUSCLE, ERECTILE DYSFUNCTION, PENILE ERECTION, RELAXATION, KINASE, NEUROTRANSMISSION, MECHANISM, RABBIT, RAT
  • Ankara University Affiliated: Yes

Abstract

Purpose: We investigated the relaxant effects of repetitive administration of L-arginine, the substrate for nitric oxide, at hourly intervals and elucidated its mechanism of action in human corpus cavernosum.