GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits

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MERAL Ö., Ozgur E., Kismali G., Guler G., Alpay M., Sel T., ...Daha Fazla

Bratislava Medical Journal, cilt.117, sa.11, ss.672-676, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 11
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4149/bll_2016_129
  • Dergi Adı: Bratislava Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.672-676
  • Anahtar Kelimeler: radiofrequency, apoptosis, caspase, cytochrome c, rabbit, IN-VITRO EXPOSURE, OXIDATIVE STRESS, PREGNANT RABBITS, BLOOD-CHEMISTRY, MOBILE PHONES, CELL-DEATH, ACTIVATION, RADIATION, CANCER, TISSUE
  • Ankara Üniversitesi Adresli: Evet

Özet

BACKGROUND: There have been several Radio Frequency (RF) field researches on various populations and groups of different ages in recent years. However, the most important group for research has been declared as the pregnant women and their babies. OBJECTIVE: The aim of the study was to analyse the effect on apoptotic factors of RF fields on newborn rabbit liver tissues. MATERIALS AND METHODS: Cytochrome c and AIF (Apoptosis Inducing Factor) levels were measured by western blot and caspase 1, 3 and 9 activities were measured by colorimetric method. RESULTS: Cytochrome c and AIF levels were not altered, but all caspase activities were increased in female infant rabbits that exposed to 1800 MHz GSM-like RF signals when they reached 1 month of age and caspase 1 and caspase 3 levels were decreased in male infant rabbits that exposed to 1800 MHz GSM-like RF signals between 15th and 22nd days of the gestational period. Results showed that 1800 MHz GSM-like RF exposure might lead to apoptosis in infant rabbit's liver tissues. CONCLUSION: According to the results, we suggest that postnatal RF exposure causes caspase dependent apoptosis in female infant rabbits liver tissues.