The effect of increased cortisol levels on serum glucagonlike peptide-1 in patients with type 2 diabetes mellitus Tip 2 diabetes mellitus hastalarindaki artmiş serum kortizol düzeyinin serum glukagon-like peptid 1 üzerine etkileri

Karadurmus N., Çakar M., Naharci M. I., Üçkaya G., ŞAHİN M., Kenan S., ...Daha Fazla

Anatolian Journal of Clinical Investigation, cilt.4, sa.2, ss.80-89, 2010 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 2010
  • Dergi Adı: Anatolian Journal of Clinical Investigation
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.80-89
  • Anahtar Kelimeler: Cortisol, Diabetes mellitus, Glucagon-like peptide-1
  • Ankara Üniversitesi Adresli: Hayır

Özet

The aim of this study is to examine the effects of increased cortisol metabolism seen in type 2 Diabetes Mellitus (DM) patients with hypercortisolism on Glucagon-like peptide-1 (GLP-1) and glycemic control and glycosilated hemoglobin levels. 36 Type 2 DM patients with normal serum cortisol level (≤18 μg/dl) and 24 Type 2 DM patients with elevated serum cortisol level (>18 μg/dl) admitted to the study and 20 healthy cases (10 men, 10 women) were included as control group. 1 mg dexamethasone suppression scanning test and serum Adrenocorticotropin hormone (ACTH) level assessment. Plasma HbA1c levels of type 2 DM patients with elevated cortisol levels were found to be significantly higher than type 2 DM patients with normal cortisol levels. Both preprandial and postprandial plasma GLP-1 levels were found to be lower in diabetic patients than healthy control cases. GLP-1, which is an important representative of incretins and found to be lower in diabetes patients than in healthy individuals particularly as a response to food intake, is seen as a new source of promise in treatment of type 2 DM and lower levels are more evident in diabetic patients with increased cortisol hormone production.