Research Information System
Anatolian Journal of Clinical Investigation, vol.4, no.2, pp.80-89, 2010 (Scopus)
The aim of this study is to examine the effects of increased cortisol metabolism seen in type 2 Diabetes Mellitus (DM) patients with hypercortisolism on Glucagon-like peptide-1 (GLP-1) and glycemic control and glycosilated hemoglobin levels. 36 Type 2 DM patients with normal serum cortisol level (≤18 μg/dl) and 24 Type 2 DM patients with elevated serum cortisol level (>18 μg/dl) admitted to the study and 20 healthy cases (10 men, 10 women) were included as control group. 1 mg dexamethasone suppression scanning test and serum Adrenocorticotropin hormone (ACTH) level assessment. Plasma HbA1c levels of type 2 DM patients with elevated cortisol levels were found to be significantly higher than type 2 DM patients with normal cortisol levels. Both preprandial and postprandial plasma GLP-1 levels were found to be lower in diabetic patients than healthy control cases. GLP-1, which is an important representative of incretins and found to be lower in diabetes patients than in healthy individuals particularly as a response to food intake, is seen as a new source of promise in treatment of type 2 DM and lower levels are more evident in diabetic patients with increased cortisol hormone production.