Synthesis and potent antimicrobial activity of some novel N-(alkyl)-2-phenyl-1H-benzimidazole-5-carboxamidines

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GÖKER A. H., Alp M., Yildiz S.

Molecules, cilt.10, sa.11, ss.1377-1386, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 11
  • Basım Tarihi: 2005
  • Doi Numarası: 10.3390/10111377
  • Dergi Adı: Molecules
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1377-1386
  • Anahtar Kelimeler: 1H-benzimidazole carboxamidines, methicillin-resistant S. aureus (MRSA), antibacterial activity and antifungal activity
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5- carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N-(2-diethylaminoethyl)-1H-benzimidazole-5- carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 μg/mL against both some bacteria and the fungus C. albicans). © 2005 by MDPI.