The role of nitric oxide synthase in reduced vasocontractile responsiveness induced by prolonged alpha(1)-adrenergic receptor stimulation in rat thoracic aorta

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GÜRDAL H., Can A., Ugur M.

BRITISH JOURNAL OF PHARMACOLOGY, cilt.145, sa.2, ss.203-210, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 145 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1038/sj.bjp.0706177
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.203-210
  • Anahtar Kelimeler: alpha(1)-adrenergic receptors, desensitization, vascular endothelium, nitric oxide, nitric oxide synthase activity, rat aorta, SMOOTH-MUSCLE CONTRACTION, PROTEIN-KINASE-C, RELAXING FACTOR, VASOCONSTRICTOR RESPONSE, IN-VITRO, ENDOTHELIUM, DESENSITIZATION, NOREPINEPHRINE, NORADRENALINE, EXPOSURE
  • Ankara Üniversitesi Adresli: Evet

Özet

1 Prolonged exposure (6 - 12 h) of rat aorta to alpha1-adrenergic receptor (alpha(1)AR) agonist phenylephrine (Phe) leads to a decrease in alpha(1)AR-mediated vasoconstriction. This reduced responsiveness to alpha(1)AR stimulation was strongly dependent on the intactness of the endothelium.