BRITISH JOURNAL OF PHARMACOLOGY, cilt.145, sa.2, ss.203-210, 2005 (SCI-Expanded)
1 Prolonged exposure (6 - 12 h) of rat aorta to alpha1-adrenergic receptor (alpha(1)AR) agonist phenylephrine (Phe) leads to a decrease in alpha(1)AR-mediated vasoconstriction. This reduced responsiveness to alpha(1)AR stimulation was strongly dependent on the intactness of the endothelium.