Akademik Veri Yönetim Sistemi
Microchemical Journal, cilt.211, 2025 (SCI-Expanded)
Pulmonary arterial hypertension represents a significant global health challenge, often culminating in cardiac failure. Selexipag (SEL), an orally administered prostacyclin receptor agonist, is crucial for mitigating the associated risks, including mortality and hospitalization. However, existing analytical methods for SEL determination are constrained by limited sensitivity, high costs, and the need for specialized operators. This study introduces a novel molecularly imprinted polymer (MIP)-based electrochemical sensor for the selective and sensitive detection of SEL in pharmaceutical and biological matrices. Using 4-aminobenzoic acid as a functional monomer, ethylene glycol dimethacrylate as a crosslinker, and a UV-induced photopolymerization process for the SEL-specific MIP sensor was created and immobilized on a glassy carbon electrode. The sensor exhibited exceptional sensitivity with a detection limit of 2.03 × 10−13 M in standard solutions and 1.19 × 10−13 M in human serum. It showed a linear range of 7.5 × 10−13 M to 7.5 × 10−12 M. Validation studies confirmed its reliability, reproducibility, and high recovery rates in commercial serum and capsule dosage forms. The sensor demonstrated robust performance amidst potential interferences, highlighting its precision and specificity. This work represents a pioneering approach to using MIP-based electrochemical platforms for SEL detection, offering an efficient and cost-effective alternative for clinical and pharmaceutical applications.