Natural killer (NK) cell cytotoxic activity and serum IL-2, IL-12, TNF-alpha and IFN-gamma levels in malignant lymphoma (ML) patients and their healthy family members

İKİNCİOĞULLARI K. A., DOĞU E. F., Egin Y., Goksel D., Reisli I., Cin S., ...Daha Fazla

14th European Immunology Meeting (EFIS 2000), Poznan, Polonya, 23 - 27 Eylül 2000, ss.417-422 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Poznan
  • Basıldığı Ülke: Polonya
  • Sayfa Sayıları: ss.417-422
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study PB NK cell cytotoxicity and IL-2,IL-12, TNF-alpha, IFN-gamma levels of serum and IL-2 stimulated PBMC supernatants were examined in 31 ML patients and their 49 family members(30 parents,19 siblings) in order to assess whether or not NK cell mediated immunity could play a role in development of-ML. There was no difference in NK cell cytotoxicity between ML patients and their healthy family members. A significant increase have been detected in serum IL-2 and IL-12 levels of ML patients compared to their healthy siblings and controls. Serum TNF-alpha and IFN-gamma levels of ML patients were also higher than the controls. Serum cytokine levels of parents of ML cases were found to be elevated compared to adult controls. High cytokine levels detected in patients could be related with low socioeconomic status which was correlating with recurrent infections and cytokine overproduction due to frequent antigenic exposure.