A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue

ELGÜN ÜLKAR S., Guney K., Tuncer M., Gokhun I.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.257, sa.3, ss.158-160, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 257 Sayı: 3
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/s004050050214
  • Dergi Adı: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.158-160
  • Anahtar Kelimeler: arginase, tonsillitis, tonsillar and adenoidal hypertrophy, NITRIC-OXIDE SYNTHASE, L-ARGININE, LYMPHOCYTE-PROLIFERATION, IMMUNE-RESPONSE, MACROPHAGES, INHIBITION, MECHANISM, LIVER, CELLS
  • Ankara Üniversitesi Adresli: Evet

Özet

Since arginase has been found to be an arginine-depleting and nitric oxide synthase-regulating enzyme, the present study was devised to examine hypertrophied and infected tonsil and adenoid arginase activity in relation to a metabolic arginase-nitric oxide pathway and its association with disease processes. Tissues were taken from 32 children undergoing adenotonsillectomy. There was a statistically significant difference between the two tissue enzyme activities, with tonsillar arginase activity being higher than the corresponding adenoidal tissue (P < 0.005). This suggests a potential role for tissue arginase activity as an outcome module and a contributing factor in chronic recurrent infection and hypertrophy of tonsillar and adenoidal tissues.