Synthesis and Antioxidant Activity of Indole Derivatives Containing 4-Substituted Piperazine Moieties

ALTUNTAŞ T., Yilmaz N., ÇOBAN T., ÖLGEN S.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.4, ss.380-386, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1570180813666161020165623
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.380-386
  • Anahtar Kelimeler: Antioxidant, free radical scavenging, piperazine, indole, LIPID-PEROXIDATION, N-H, ANALOGS, MELATONIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Oxidative stress caused by reactive oxygen species (ROS) plays a significant role in many human disorder such as cancer, rheumatoid arthritis, atherosclerosis, stroke, neurodegeneration, and diabetes as well as the process of aging. Compounds interfere with the action of ROS might be useful in prevention and treatment of these pathologies. Indole nucleus seems to protect the nervous system against oxidative stress.