Research Information System
14th World Congress of the International College of Nutrition (ICN)/5th Congress of the International College of Cardiology (ICC), Koshice, Slovakia, 4 - 07 June 2009, pp.91-94
Oxidation of lipoprotein molecules in vascular areas are considered to be important steps in the pathogenesis of atherosclerosis. Paraoxonase 1 (PON1) prevents LDL oxidation. We aimed to investigate the importance of PON1 192Q/R polymorphism in atherosclerotic patients. 65 atherosclerotic patients and 45 healthy controls were included. Genotyping of polymorphism were carried out by PCR-RFLP. The frequency of QQ, QR and RR genotype of PON1 were 36.9%, 44.6%, 18.5% and 55.6%, 44.4%, 0% in the patient and control groups respectively. There were significant differences between groups in terms of distribution of PON1 genotype (p=0.006) and allele frequencies (p=0.004). Individuals carrying at least one R allele have a 2.409 times higher risk for atherosclerosis than those who have null genotypes for the R allele (OR=2.409; 95% CI, 1,312-4.424). This study suggests that 192Q/R polymorphism may be an important risk factor in susceptibility to atherosclerosis.