Vascular endothelial growth factor (VEGF)-C and its receptors, soluble VEGFR-2 and VEGFR-3, in polycystic ovary syndrome

Ozen F. Z., KAYA SEZGİNER E., KIRLANGIÇ Ö. F., Taskomur A. T., AKTAN F., Kaplan G., ...More



Objectives Angiogenesis is involved in polycystic ovary syndrome (PCOS) progression. Vascular endothelial growth factor C (VEGF-C) and its receptors are key angiogenic markers. The main objective of this study was to investigate the serum levels of VEGF-C and its receptors, soluble VEGF receptor 2 (sVEGFR-2) and VEGFR-3, in patients with PCOS and healthy controls and determine the link between serum levels of these VEGF-related proteins and the biochemical and hormonal data of patients with PCOS. Methods Thirty-six women with PCOS and 30 controls were included in this study. The measurement of VEGF-C, sVEGFR-2, and VEGFR-3 levels in serum and routine biochemical and hormone analysis were performed. Results In the PCOS group, significantly higher serum sVEGFR-2 levels and no significant differences in serum VEGF-C and VEGFR-3 were observed compared to the controls. Serum sVEGFR-2 levels exhibited positive associations with VEGF-C, VEGFR-3, total cholesterol, and anti-mullerian hormone (AMH) in women with PCOS. Moreover, a positive correlation between serum VEGF-C and VEGFR-3 concentrations was detected in patients with PCOS. The cutoff value of serum sVEGFR-2 was 4.24 ng/mL (sensitivity 68 %, specificity 64 %) to distinguish PCOS. Conclusions Despite unaltered levels of serum VEGF-C and VEGFR-3, there was an association between circulating levels of sVEGFR-2 and these VEGF-related proteins. sVEGFR-2 could be a promising diagnostic biomarker for PCOS. Regarding the significant correlation between sVEGFR-2 and AMH, sVEGFR-2 could have an impact on the hormonal elements of PCOS. Further studies are warranted to fully understand the function of VEGF-C and its receptors in PCOS.