Fetal hydrops and anemia as signs of Down syndrome

ŞÜKÜR Y. E., Gozukucuk M., Bayramov V., KOÇ F. A.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, cilt.110, sa.11, ss.716-718, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 110 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jfma.2011.09.009
  • Dergi Adı: JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.716-718
  • Anahtar Kelimeler: Down syndrome, fetal hydrops, pancytopenia, myelopoiesis, TRANSIENT MYELOPROLIFERATIVE DISORDER, PRENATAL-DIAGNOSIS, MANAGEMENT, ALLOIMMUNIZATION, TRISOMY-21, LEUKEMIA
  • Ankara Üniversitesi Adresli: Evet

Özet

Before the 20(th) week of gestation, the most common cause of nonimmune hydrops fetalis is chromosomal abnormalities. Herein, we report a case of fetal hydrops, anemia, and intrauterine growth retardation that presented at 27 weeks of gestation with a negative chromosomal abnormality screening. Cordocentesis and karyotype analysis revealed fetal pancytopenia and Down syndrome. Down syndrome rarely presents with fetal hydrops and anemia. Therefore, when hydrops and anemia are diagnosed, especially in the second trimester of gestation, the possibility of Down syndrome should be kept in mind. In addition, if the pregnancy results in a live birth, the baby should be examined for transient abnormal myelopoiesis. Copyright (C) 2011, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.