Ultrasound-Assisted One‐Pot Synthesis of 9-(Substituted heteroaryl) acridinedione Derivatives


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BAYRAMOĞLU D., ÖZGÜR M.

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, cilt.9, ss.1610-1620, 2021 (Hakemli Dergi) identifier

Özet

An efficient green approach for the synthesis of 9-heteroaryl-acridine-1,8-dione derivatives (3a-f) was accomplished viareactions of dimedone (1) with various heteroaromatic aldehydes(2a-f) and ammonium acetate through one-pot multicomponent reactions in water under mild conditions using ultrasound irradiation in excellent yields. Of the synthesized compounds, 3d-fwere novel and this process presents the advantages of high yields andeasy work-up procedures. Spectral analyses were accomplished by FTIR, 1H NMR, 13C NMR and LC-MS TOF analyses