Hepatitis B core antigen expression pattern reflects the response to anti-viral treatment

Uzun Y., Bozkaya H., Erden E., Cinar K., Idilman R., Yurdaydin C., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.21, sa.6, ss.977-981, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1440-1746.2006.04263.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.977-981
  • Anahtar Kelimeler: chronic hepatitis B, HBcAg, interferon, lamivudine, PCNA, HEPATOCYTE PROLIFERATION, NUCLEAR-LOCALIZATION, VIRUS-INFECTION, REPLICATION, COMBINATION, LAMIVUDINE, SURFACE
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: In hepatitis B early antigen (HBeAg)-negative patients, response predictors to current treatment regimens are not well known. Hepatocyte cell cycle may influence hepatitis B virus (HBV) replication and hepatitis B core antigen (HBcAg) expression, which is a major target for antiviral immune response. The aim of the present paper was to evaluate the role of HBcAg expression in liver tissue and the rate of hepatocyte proliferation in response to antiviral treatment in chronic hepatitis B.