Serum Zonulin Levels Are Higher Among Children with Autism Spectrum Disorders and Correlated with Social Impairment

Kara H., AÇIKEL S. B., Cetinkaya M., Tuncer S. C.

ALPHA PSYCHIATRY, cilt.22, sa.5, ss.250-256, 2021 (SCI-Expanded, SSCI, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5152/alphapsychiatry.2021.21152
  • Dergi Adı: ALPHA PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.250-256
  • Anahtar Kelimeler: Autistic disorder, psychosocial functioning, haptoglobins, epithelium, INTESTINAL PERMEABILITY, GUT PERMEABILITY, LIFETIME VERSION, RELIABILITY, VALIDITY, SCHIZOPHRENIA, SCHEDULE
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Zonulin is a protein that affects the integrity of intercellular connections in the intestines. It has been emphasized that autoimmune diseases as well as neurodevelopmental disorders, for example autism spectrum disorder (ASD), may occur through alterations in intestinal permeability and blood-brain barrier. We aimed to investigate the gastrointestinal permeability of individuals with ASD by determining serum zonulin levels and their relationship to symptom severity.