Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Leukemic Hematopoiesis

Akalin I., Koca E., KARABULUT H. G., Haznedaroglu I. C., Cetiner D., Hayran M., ...Daha Fazla

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.21, sa.1, ss.1-9, 2011 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4999/uhod.09164
  • Dergi Adı: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: Angiotensin converting enzyme, Local renin-angiotensin system, ACE I/D gene polymorphism, Angiotensin II, Leukemic hematopoiesis, ACUTE MYELOID-LEUKEMIA, BREAST-CANCER RISK, BONE-MARROW, DELETION POLYMORPHISM, MYOCARDIAL-INFARCTION, SYSTEM EXPRESSION, I/D POLYMORPHISM, HUMAN FOREARM, RENIN, ACE
  • Ankara Üniversitesi Adresli: Evet

Özet

Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin converting enzyme (ACE) converts angiotensinogen-I to its physiologically active peptide angiotensinII, which stimulates proliferation and differentiation of hematopoietic stem cells through angiotensin II type 1 receptors. We investigated the ACE insertion/deletion (I/D) gene polymorphisms in patients with hematological malignancies including acute and chronic leukemia, myelodysplastic syndrome and multiple myeloma. Our results showed that 80.4% of the patients represented ID/II genotype, whereas it was 55.9% of the control group and 3.2 fold increased disease risk in the existence of insertion allele (ID/II). This is the first study demonstrating possible effects of ACE I/D gene polymorphism of the local bone marrow RAS components on leukemic hematopoiesis.