Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Leukemic Hematopoiesis

Akalin I., Koca E., KARABULUT H. G., Haznedaroglu I. C., Cetiner D., Hayran M., ...More

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.21, no.1, pp.1-9, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.4999/uhod.09164
  • Journal Name: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-9
  • Keywords: Angiotensin converting enzyme, Local renin-angiotensin system, ACE I/D gene polymorphism, Angiotensin II, Leukemic hematopoiesis, ACUTE MYELOID-LEUKEMIA, BREAST-CANCER RISK, BONE-MARROW, DELETION POLYMORPHISM, MYOCARDIAL-INFARCTION, SYSTEM EXPRESSION, I/D POLYMORPHISM, HUMAN FOREARM, RENIN, ACE
  • Ankara University Affiliated: Yes

Abstract

Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin converting enzyme (ACE) converts angiotensinogen-I to its physiologically active peptide angiotensinII, which stimulates proliferation and differentiation of hematopoietic stem cells through angiotensin II type 1 receptors. We investigated the ACE insertion/deletion (I/D) gene polymorphisms in patients with hematological malignancies including acute and chronic leukemia, myelodysplastic syndrome and multiple myeloma. Our results showed that 80.4% of the patients represented ID/II genotype, whereas it was 55.9% of the control group and 3.2 fold increased disease risk in the existence of insertion allele (ID/II). This is the first study demonstrating possible effects of ACE I/D gene polymorphism of the local bone marrow RAS components on leukemic hematopoiesis.