Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study

Herdi O., Sayar-Akaslan D., İLHAN R. S., ÇOLAK B., DUMAN B.

PSYCHIATRY RESEARCH, cilt.290, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 290
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.psychres.2020.113065
  • Dergi Adı: PSYCHIATRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Anahtar Kelimeler: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Obsessive-compulsive disorder, Fluoxetine equivalent dose, Inflammation, NEUTROPHIL-LYMPHOCYTE RATIO, OBSESSIVE-COMPULSIVE DISORDER, MAJOR DEPRESSIVE DISORDER, PLATELET-LYMPHOCYTE, NEUTROPHIL/LYMPHOCYTE RATIO, BIPOLAR DISORDER, TNF-ALPHA, METAANALYSIS, IMPACT
  • Ankara Üniversitesi Adresli: Evet

Özet

Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of this study was to examine the association between OCD and subclinical inflammatory markers, namely neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in adult patients and to investigate the association between antidepressant medications and NLR, PLR. Electronic medical records(EMR) of 24,635 patients aged 18-64 were reviewed and after exclusion of comorbid psychiatric and medical diagnosis 135 EMR of OCD patients were included into final analyses and compared with the healthy control group (n = 133). Blood cell counts were noted to calculate NLR and PLR. Medications of patients were gathered from all patients to calculate fluoxetine-equivalent-dose(FED) to examine the effects of antidepressants on NLR and PLR. NLR and PLR were significantly higher in OCD. Contrary to the correlation of FED with NLR, PLR was found to not correlate with FED. Hence, PLR would be considered as a robust biomarker to medication effect contrary to NLR. OCD was significantly predicted by both NLR and PLR in logistic regression analyzes.