Relationship between toll-like receptor 8 gene polymorphisms and pediatric pulmonary tuberculosis

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Dalgic N., TEKİN D., Kayaalti Z., Cakir E., Soylemezoglu T., SANCAR M.

DISEASE MARKERS, cilt.31, sa.1, ss.33-38, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1155/2011/545972
  • Dergi Adı: DISEASE MARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-38
  • Anahtar Kelimeler: Children, pulmonary tuberculosis, single nucleotide polymorphism, Toll-like receptor 8, VIRAL-INFECTION, RECOGNITION, EXPRESSION, RESPONSES, IMMUNITY
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: Genetic variants in Toll-like receptors (TLRs) are considered a potential indicator for host susceptibility to and outcome of several infectious diseases including tuberculosis. The aim of this study was to determine whether -129 C/G and Met1Val polymorphisms of TLR8 were associated with pediatric pulmonary tuberculosis in Turkish population.