Harnessing Stem Cell Potential for the Treatment of Erectile Function in Men with Diabetes Mellitus: From Preclinical/Clinical Perspectives to Penile Tissue Engineering

GÜR S., Hellstrom W. J. G.

CURRENT STEM CELL RESEARCH & THERAPY, cilt.15, sa.4, ss.308-320, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1574888x14666190828142045
  • Dergi Adı: CURRENT STEM CELL RESEARCH & THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.308-320
  • Anahtar Kelimeler: Stem cell, diabetes mellitus, preclinical, erectile dysfunction, clinical trials, tissue engineering, UMBILICAL-CORD BLOOD, SHOCK-WAVE THERAPY, ENDOTHELIAL PROGENITOR CELLS, BONE-MARROW, RAT MODEL, SEXUAL DYSFUNCTION, INTRACAVERNOUS INJECTION, EXTRACELLULAR-MATRIX, POSSIBLE MECHANISMS, INSULIN-RESISTANCE
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: According to the World Health Organization, more than 150 million people are diabetic, and this number will increase twofold by the year 2025. Diabetes-related complications affect all body organ systems, including the penis. Diabetes-induced Erectile Dysfunction (ED) is caused by neuropathy of the penile nerves and vasculopathy involving the smooth muscle and endothelium of the corpus cavemosum.