Chiral Sensing as a Future Challenge in Electroanalytical Chemistry: Cyclodextrin-Based Chiral Sensors

KARADURMUŞ L., GÜMÜŞTAŞ M., Bakirhan N. K., Ozkan S. A.

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, cilt.53, sa.3, ss.498-519, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 53 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/10408347.2021.1967108
  • Dergi Adı: CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.498-519
  • Anahtar Kelimeler: Chiral drugs, chirality, cyclodextrin, electrochemistry, sensor, SUPERCRITICAL-FLUID CHROMATOGRAPHY, OF-THE-ART, 2-DIMENSIONAL GAS-CHROMATOGRAPHY, PERFORMANCE LIQUID-CHROMATOGRAPHY, MOLECULARLY IMPRINTED POLYMERS, LEADING ELECTROLYTE ADDITIVES, SINGLE-ENANTIOMER DRUGS, GLASSY-CARBON ELECTRODE, GRAPHENE QUANTUM DOTS, L-ASCORBIC-ACID
  • Ankara Üniversitesi Adresli: Evet

Özet

Chirality is an academically exciting and interesting topic, as most active ingredients have chirality. Chiral enantiomers with the same molecular shape show different effects from each other in terms of pharmacological, pharmacokinetic, and toxicology. There are many examples of these differences that have caused dramatic, even fatal damage. For these reasons, it is of great importance to developing an effective method to achieve chiral identification and separation, and chiral separation methods are becoming increasingly important in both the pharmaceutical industry and clinical studies. Electrochemical techniques, which can provide many advantages over other classical methods, have attracted great interest in chiral recognition in recent years. In this review, extensive and critical research of the trends in chiral recognition in recent studies is explained. Especially the role of cyclodextrins derivatives in chiral analysis has been investigated and the studies related to this are explained and given in the tables. In addition, some remarks and future perspectives in the field of chiral recognition are also discussed in the concluding part.