The effects of Ankaferd (R) Blood Stopper on transcription factors in HUVEC and the erythrocyte protein profile

YILMAZ E., Gulec S., Torun D., HAZNEDAROĞLU İ. C., Akar N.

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.4, ss.276-285, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.39
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.276-285
  • Anahtar Kelimeler: Ankaferd (R), endothelium, transcription factors, erythrocyte, MEDICINAL-PLANT EXTRACT, VITRO ANTIBACTERIAL ACTIVITIES, HEMOSTATIC ACTIONS, IN-VITRO, REGULATE TRANSCRIPTION, BLEEDING MODEL, GENE PROMOTER, TUMOR-GROWTH, EXPRESSION, EFFICACY
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Ankaferd (R) Blood Stopper (ABS) is an herbal extract that has historically been used as a hemostatic agent in traditional Turkish medicine. ABS is comprised of a standardized herbal mixture of T vulgaris, G. glabra, V vinifera, A. officinarum, and U. dioica. ABS's basic mechanism of action is the formation of an encapsulated protein web, which represents the focal point for vital erythrocyte masses. The hemostatic effects of ABS have been observed in vitro and in vivo. ABS was registered as a hemostatic agent for external hemorrhages and dental bleeding following phase I randomized, double-blind crossover placebo-controlled clinical research, and safety and efficacy reports. In terms of the potential use of ABS, transcription factors may be novel factors that play a role in the hemostatic and other pleiotropic effects of ABS.