Akademik Veri Yönetim Sistemi
Turkish Journal of Biochemistry, cilt.34, sa.3, ss.187-194, 2009 (SCI-Expanded)
Objectives: The aim of this study is to investigate thioredoxin reductase and glutathione peroxidase activities in malignant and benign lesions of breast. Methods: We have investigated thioredoxin reductase and glutathione peroxidase activities spectrophotometrically in 32 patients (breast cancer, fibroadenoma and fibrocystic disease) in malignant and benign lesions of breast. Tissue samples were taken from each patient from both tumor and healthy tissue surrounding the tumor. Enzyme activities in tumor tissues were compared with the healthy peritumoral tissue samples in both benign and malignant lesions. Results: There was a statistically significant difference for both of the enzyme activities in tumoral tissue samples than healthy tissue samples in both benign and malignant lesions (p < 0,001). Conclusion: We reported that thioredoxin reductase and glutathione peroxidase have been increased activities in patients with tumors of the breast when compared with healthy tissues. This study aimed these enzymes may be a marker in cancerous lesions with respect to breast tumors. Unfortunately higher enzyme levels in both benign and malignant lesions compared with normal tissues shows that these enzymes are not specific for only malign diseases in breast. High enzyme activity levels in breast tumors may be an adaptive response to oxidative stresses through enhanced antioxidant defense systems. © TurkJBiochem.com.