FRESENIUS ENVIRONMENTAL BULLETIN, cilt.30, sa.6A, ss.6734-6743, 2021 (SCI-Expanded)
Ninety human pharmaceuticals as xenochemicals which belong to different therapeutic were investigated in Golbasi, Azaph and lnekli Lakes. Turkey. Solid phase extraction and liquid chromatography tandem mass spectrometry were used to measure residues in lake waters. Only eighteen human pharmaceuticals were identified and quantified because the others could not be detected in these three lakes. Carbamazepine (0.002-0.11 ng/L), lidocaine (0.09-4.83 ng/L) and caffeine (0.50-12.32 ng/L) were the most frequently (%100) detected compounds. The detected concentration levels were at low ng/L levels. Five most frequently detected human pharmaceuticals (carbamazepine. citalopram, venlafaxine, lidocaine, caffeine) were selected for the environmental risk assessments. The results suggested that environmental risks of human pharmaceuticals in these lakes are negligible (risk quotient <0.01) because of their relatively low contamination levels. The data obtained will he useful for enriching pollutant investigations and environmental research in freshwater lakes,