Design, Optimization, and Characterization of Lysozyme-Loaded Poly(epsilon-Caprolactone) Microparticles for Pulmonary Delivery

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DEVRİM GÖKBERK B., Erdinc N.

JOURNAL OF PHARMACEUTICAL INNOVATION, vol.18, no.1, pp.325-338, 2023 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 18 Issue: 1
• Publication Date: 2023
• Doi Number: 10.1007/s12247-022-09648-8
• Journal Name: JOURNAL OF PHARMACEUTICAL INNOVATION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, INSPEC
• Page Numbers: pp.325-338
• Keywords: Microparticles, Optimization, Lysozyme, Cystic fibrosis, Pulmonary delivery, ANTIMICROBIAL PEPTIDES, IN-VITRO, PROTEIN, MICROSPHERES, DRUG, ACID), ENCAPSULATION, STABILITY, CARRIER
• Ankara University Affiliated: Yes

Abstract

Purpose The success of the treatment of lung diseases with minimized side effects depends on the optimum design of micro-particulate systems for pulmonary delivery that provide local delivery of drugs. This study aims to develop and evaluate optimized drug delivery systems against cystic fibrosis for pulmonary delivery.