EXPRESSION OF THE IG-ASSOCIATED HETERODIMER (MB-1 AND B29) IN HODGKINS-DISEASE

KUZU I., DELSOL G., JONES M., GATTER K., MASON D.

HISTOPATHOLOGY, cilt.22, sa.2, ss.141-144, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1111/j.1365-2559.1993.tb00092.x
  • Dergi Adı: HISTOPATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.141-144
  • Anahtar Kelimeler: HODGKINS DISEASE, B-CELL MARKERS, LYMPHOCYTE PREDOMINANCE, REED-STERNBERG CELLS, ANTIGEN RECEPTOR COMPLEX, LYMPHOID-CELLS, CD3 ANTIGEN, B-CELLS, J-CHAIN, IMMUNOGLOBULIN, DIFFERENTIATION, ANTIBODIES, TISSUE
  • Ankara Üniversitesi Adresli: Hayır

Özet

Eighty-three cases of Hodgkin's disease were studied immunocytochemically for the presence of the Ig associated heterodimer (mb-1 and B29) which is believed to be a specific pan B-cell marker. These results were compared with those achieved using other B-cell markers against CD19, CD20 and CD22. Although a small number of cases of nodular sclerosis and mixed cellularity subtype showed positivity for CD19, CD20 or CD22, no case showed any reactivity with antibodies against mb-1 or B29. This contrasted markedly with the cases of lymphocyte predominance where all seven cases expressed one or more of the B-cell antigens, with six cases being positive for mb-1. These results confirm previous studies that have suggested lymphocyte-predominance Hodgkin's disease is of B-cell origin and different from the other subtypes. However, they do not provide support for the thesis that these other subtypes may also have a B-cell origin, albeit with a different phenotype to lymphocyte predominance.