EXPRESSION OF THE IG-ASSOCIATED HETERODIMER (MB-1 AND B29) IN HODGKINS-DISEASE
HISTOPATHOLOGY, cilt.22, sa.2, ss.141-144, 1993 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 2
- Basım Tarihi: 1993
- Doi Numarası: 10.1111/j.1365-2559.1993.tb00092.x
- Dergi Adı: HISTOPATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.141-144
- Anahtar Kelimeler: HODGKINS DISEASE, B-CELL MARKERS, LYMPHOCYTE PREDOMINANCE, REED-STERNBERG CELLS, ANTIGEN RECEPTOR COMPLEX, LYMPHOID-CELLS, CD3 ANTIGEN, B-CELLS, J-CHAIN, IMMUNOGLOBULIN, DIFFERENTIATION, ANTIBODIES, TISSUE
- Ankara Üniversitesi Adresli: Hayır
Özet
Eighty-three cases of Hodgkin's disease were studied immunocytochemically for the presence of the Ig associated heterodimer (mb-1 and B29) which is believed to be a specific pan B-cell marker. These results were compared with those achieved using other B-cell markers against CD19, CD20 and CD22. Although a small number of cases of nodular sclerosis and mixed cellularity subtype showed positivity for CD19, CD20 or CD22, no case showed any reactivity with antibodies against mb-1 or B29. This contrasted markedly with the cases of lymphocyte predominance where all seven cases expressed one or more of the B-cell antigens, with six cases being positive for mb-1. These results confirm previous studies that have suggested lymphocyte-predominance Hodgkin's disease is of B-cell origin and different from the other subtypes. However, they do not provide support for the thesis that these other subtypes may also have a B-cell origin, albeit with a different phenotype to lymphocyte predominance.