Trace elements (copper, zinc and selenium) in acute COPD exacerbation

Koc U., KARNAK D., Kavas G. O., KAYACAN O.

TRACE ELEMENTS AND ELECTROLYTES, cilt.29, sa.1, ss.59-64, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5414/tex01219
  • Dergi Adı: TRACE ELEMENTS AND ELECTROLYTES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.59-64
  • Anahtar Kelimeler: acute exacerbation, COPD, copper, selenium, trace elements, zinc, OBSTRUCTIVE PULMONARY-DISEASE, GLUTATHIONE-PEROXIDASE, OXIDATIVE STRESS, PATHOGENESIS, RESPONSES, IMBALANCE, SMOKERS, ASTHMA
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: COPD is one of the major health problems deteriorating the health status of the subject. Serum levels of the trace elements are influenced by inflammation. This study was conducted to determine their serum levels in COPD acute exacerbations. Material and methods: 30 COPD patients (according to GOLD'06 criteria) with acute exacerbations (M/F: 18/12; mean age 68.8 +/- 9.5 y) and 20 healthy subjects (MAT: 12/8; mean age: 65.5 +/- 11.3 y) were studied. Trace elements in the sera of study and control subjects were measured by atomic absorption spectrophotometry. After 6 - 8 weeks of exacerbation, trace elements were remeasured in COPD subjects in the stable period. Results: In COPD patients scrum copper level in stable period (121.5 +/- 23.5 mu g/dl) was significantly higher than that of acute exacerbation (107.5 +/- 20.8 mu g/dl) (p < 0.01). Serum copper and selenium levels were higher as compared to healthy subjects (p < 0.01). However, serum zinc level was higher in healthy controls as compared to only stable period of COPD patients (p < 0.05). A positive correlation between serum copper level and erythrocyte sedimentation rate; and leukocyte count (p < 0.05, r: 0.5; p < 0.05, r: 0.4) were observed. Conclusion: Findings of this study suggest that elevation of copper and selenium may indicate the chronic inflammation in stable COPD whereas decreased levels of copper in acute phase may show the consumption. Serum zinc level was observed higher in controls than that of COPD; reflecting again chronic inflammation and consumption together. These trace elements have key roles in inflammation and these results should be supported by further large scaled studies.